Journal: BMC Pharmacology & Toxicology
Article Title: Assessing solubility of meloxicam in age-specific gastric and intestinal media relevant to adults and pediatric populations: implications for optimizing dosing in patients for postoperative pain
doi: 10.1186/s40360-024-00799-7
Figure Lengend Snippet: Solubility values of meloxicam in the simulated A fasted-state gastric media, B fasted-state intestinal media, C fed-state gastric media, and D fed-state intestinal media. FaSSGF gastric fluid simulating the fasted-state in adults, Pn-FaSSGF gastric fluid simulating the fasted-state in neonates (birth to 27 days), Pi-FaSSGF gastric fluid simulating the fasted-state in infants (1–12 months), FeSSGF intestinal fluid simulating fed-state in adults, Pnc-FeSSGF gastric fluid simulating cow’s milk-based formula fed-state in neonates (birth to 27 days), Pns-FeSSGF gastric fluid simulating soy-based formula fed-state in neonates (birth to 27 days), FaSSIF.v2 intestinal fluid simulating fasted-state in adults, P-FaSSIF-50% intestinal fluid simulating fasted-state in pediatrics when the bile salt levels are 50% (i.e., 1.5 mM) of the adult bile salt levels, P-FaSSIF-150% intestinal fluid simulating fasted-state in pediatrics when he bile salt levels are 150% (i.e., 4.5 mM) of the adult bile salt levels, FeSSIF.v2 intestinal fluid simulating fed-state in adults, Pnb-FeSSIF intestinal fluid simulating breastmilk fed-state in neonates (birth to 27 days), Pnc-FeSSIF intestinal fluid simulating cow’s milk-based formula fed-state in neonates (birth to 27 days), Pi-FeSSIF intestinal fluid simulating cow’s milk-based formula fed-state in infants (1–12 months), PF Phenyl free
Article Snippet: While ChemAxon predicted a logP value for meloxicam lower than that of metoprolol (1.6 vs. 1.76), ALOGPS predicted a logP value for meloxicam higher than that of metoprolol (2.88 vs. 1.80).
Techniques: Solubility
